Foamy Viruses, Bet, and APOBEC3 Restriction
نویسندگان
چکیده
منابع مشابه
Restriction of foamy viruses by APOBEC cytidine deaminases.
Foamy viruses (FVs) are nonpathogenic retroviruses infecting many species of mammals, notably primates, cattle, and cats. We have examined whether members of the apolipoprotein B-editing catalytic polypeptide-like subunit (APOBEC) family of antiviral cytidine deaminases restrict replication of simian FV. We show that human APOBEC3G is a potent inhibitor of FV infectivity in cell culture experim...
متن کاملThe foamy viruses.
INTRODUCTION ........................................ 169 HISTORY ........................................ 170 CLASSIFICATION AND NOMENCLATURE .................................. 170 PROPERTIES OF VIRUSES ......... .......................... 170 Isolations and serological relationships ................................... 170 Morphology ........................................ 171 Physical and ch...
متن کاملFoamy virus Bet proteins function as novel inhibitors of the APOBEC3 family of innate antiretroviral defense factors.
Foamy viruses are a family of complex retroviruses that establish common, productive infections in a wide range of nonhuman primates. In contrast, humans appear nonpermissive for foamy virus replication, although zoonotic infections do occur. Here we have analyzed the ability of primate and mouse APOBEC3G proteins to inhibit the infectivity of primate foamy virus (PFV) virions produced in their...
متن کاملEvolution of Foamy Viruses:
Recent evidence indicates that foamy viruses (FVs) are the oldest retroviruses (RVs) that we know and coevolved with their hosts for several hundred million years. This coevolution may have contributed to the non-pathogenicity of FVs, an important factor in development of foamy viral vectors in gene therapy. However, various questions on the molecular evolution of FVs remain still unanswered. T...
متن کاملA Novel Bayesian Method for Detection of APOBEC3-Mediated Hypermutation and Its Application to Zoonotic Transmission of Simian Foamy Viruses
Simian Foamy Virus (SFV) can be transmitted from non-human primates (NHP) to humans. However, there are no documented cases of human to human transmission, and significant differences exist between infection in NHP and human hosts. The mechanism for these between-host differences is not completely understood. In this paper we develop a new Bayesian approach to the detection of APOBEC3-mediated ...
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ژورنال
عنوان ژورنال: Viruses
سال: 2021
ISSN: 1999-4915
DOI: 10.3390/v13030504